学术报告

　　报告题目： Targeting protective and toxic prostaglandin receptors in neurologic disorders 

　　报告人：Dr. Katrin Ingrid Andreasson 

　　Associate Professor of Neurology at the Stanford University Medical Center 

　　联系人：林鑫华研究员唐铁山研究员

　　报告时间：2013年10月18日下午2：00 

　　报告地点：中科院动物所 B座105会议室

　　Dr. Andreasson is currently an Associate Professor in Stanford University. She is interested in understanding the basic mechanisms by which neurons die in stroke and in neurodegenerative disease, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Her focus is on the cyclooxygenase-2 (COX-2) pathway, which has been found to play a critical role in promoting neuronal death in a number of models of neurological disease, including stroke, Parkinson’s disease, amyotrophic lateral sclerosis, and Alzheimer’s disease. She is examining the function of downstream prostaglandin receptor signaling pathways, focusing on the functions of prostaglandin receptors in glutamate toxicity, ischemia, and neuroinflammation. Using a combination of in vitro and in vivo genetic and pharmacological strategies, she is finding that specific prostaglandin receptor signaling pathways impact dramatically on disease progression in models of both acute and chronic neurodegeneration. The long-term goal of her research is to understand the contribution of prostaglandin signaling to neuronal injury in a wide array of neurological diseases and to develop therapeutic strategies targeting these pathways in human disease.