北京大学生命科学学院
学术报告

题目：Micron scale patterning of the fluid phospholipid bilayer: Mechanisms and Clinical Implications

报告人：Vann Bennett
George Barth Geller Professor,
Department of Biochemistry Cell Biology, and Neurobiology,
Duke University Medical Center
Investigator, Howard Hughes Medical Institute

时间：2013年6月7日（周五），下午13:00-14:30 PM

地点：生命科学学院一楼邓祐才报告厅

Abstract:
Biological membranes have evolved mechanisms for organization of ion transporters and other membrane-spanning proteins into functional microdomains, even though their phospholipid bilayers are fluid with a viscosity of a light olive oil. These membrane domains are responsible for much of vertebrate physiology and are of considerable clinical importance. The seminar today will discuss the discovery of ankyrin adaptors and their functions in coordinating diverse membrane-spanning proteins and coupling these proteins to a spectrin lattice on the cytoplasmic surface of the plasma membrane. Ankyrin/spectrin-based domains include excitable membranes in the nervous system and heart, lateral membranes of epithelial cells, inner and outer segments of photoreceptors, and costameres of striated muscle. A simple mechanism for facile acquisition of ankyrin-binding activity will be presented that can explain the diverse nature and recent evolution of ankyrin-binding partners. New data will also be presented showing that ankyrin is not just a static scaffolding protein but exhibits dynamic interactions with its partners, interacts with the membrane through palmitoylation, and participates as an adaptor for the dynactin complex to promote directed intracellular transport of membrane proteins.

联系人：张研（电话：62754880）

欢迎各位老师和同学积极参加！

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