学术报告
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发表日期： 2014-10-14 |
来源：膜室 |
发稿人：范利华 |
报告题目：Control of signalling by the rhomboid-like superfamily
报告人：Prof. Matthew Freeman，Dunn School of Pathology ，University of Oxford
邀请人：林鑫华研究员 010-64807970
报告时间：2014年10月21日（周二）上午10:00
报告地点：中科院动物所 B105会议室
Matthew Freeman is Professor of Pathology and Head of Sir William Dunn School of Pathology. The main questions they study are what cellular mechanisms regulate signalling between animal cells, and how that signalling controls biological functions like development and physiology.
Their focus recently has been on the rhomboid family of proteins. More recently they have become interested in non-catalytic rhomboid-like proteins. They are also pursuing the potential medical significance of their basic discoveries, which includes cancer, inflammation, metabolic disorders and infectious diseases.
Representative Publications:
1、Freeman, M. (2014). The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles. Annu Rev Cell Dev Biol. DOI: 10.1146/annurev-cellbio-100913-012944
2、Adrain, C., Zettl, M., Christova, Y., Taylor, N. and Freeman, M. (2012). TNF signalling requires iRhom2 to promote trafficking and activation of TACE. Science, 335, 225-8.
3、Zettl, M., Adrain, C., Strisovsky, K., Lastun, V., and Freeman, M. (2011). Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling. Cell, 145, 79-91.
4、Urban, S., Lee, J.R. and Freeman, M. (2001). Drosophila Rhomboid-1 defines a novel family of putative intramembrane serine proteases. Cell, 107, 173-182.
5、 Lee. J.R., Urban, S., Garvey, C.F. and Freeman, M. (2001). Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila. Cell, 107, 161-171.
6、Freeman, M. (2000). Feedback control of developmental signalling. Nature, 408, 313-319.
7、Casci, T., Vinós, J. and Freeman, M. (1999). Sprouty, an intracellular inhibitor of Ras signalling. Cell, 96, 655-665.
8、Wasserman, J.D. and Freeman, M. (1998). An autoregulatory cascade of EGF receptor signalling patterns the Drosophila egg.Cell, 95, 355-364.
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