报告题目：A cellular mechanism for coin flip: the Notch signaling pathway　　

　　报告人：Prof. Raphael Kopan　　

　　Cincinnati Children's Hospital Medical Center University of 　　

　　Cincinnati College of Medicine　　

　　邀请人：林鑫华研究员  010-64807970　　

　　报告时间：2015年9月21日（周一）上午10:00　　

　　报告地点：中国科学院动物研究所 C101会议室　　

　　Raphael Kopan, PhD, who is a professor of developmental biology at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine, has carried out seminal work in the field of Notch biology. This work has, and continues to have, an enormous impact on our understanding of normal tissue development and renewal, Alzheimer's disease and cancer-related research. 　　

　　In deciphering the mode of Notch activation and demonstrating the use of inhibitors to modulate Notch activity, Dr. Kopan's work laid the groundwork for the therapeutic use of γ-secretase inhibitors in the treatment of cancers, currently in clinical trials. His current interests in organogenesis are focused on two modular organs - skin and kidney - in which his group is trying to understand how interplay among the same seven pathways results in activation of distant programs.　　

　　Dr. Kopan's work has resulted in 120 scientific articles as of 2013. He is the co-inventor of one patent, and he has served on scientific advisory boards as well as being a consultant to the pharmaceutical industry 

　　Representative Publications:　　

　　1、  Jarriault S, Brou C, Logeat F, Schroeter E H, Kopan R and Israël A:  Signaling downstream of activated mammalian Notch.  Nature (1995) 377:355-358. 　　

　　2、  Schroeter EH, Kisslinger JA and Kopan R: Notch 1 signaling requires ligand-induced proteolytic release of intracellular domain. Nature (1998) 393:382-386.　　

　　3、  De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A and Kopan R: A Presenilin-1-dependent, g-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 398:518-522.　　

　　4、  *Huppert S, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner L and Kopan R:  Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature (2000) 405:966-970.　　

　　5、  Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K and Xiao ZC: F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell (2003) 115:163-175.　　

　　6、  Demehri S, Turkoz A and Kopan R: Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell (2009) 16:55-66.PMC2705757　　

　　7、  Demehri, S., Turkoz, A., Manivasagam, S., Yockey, L.J., Turkoz, M., and Kopan, R. Elevated Epidermal Thymic Stromal Lymphopoietin Levels Establish An Anti-Tumor Environment In The Skin. Cancer Cell (2012) 22: 494-505.PMC3480666

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