Label-free Optical Technologies for Histologic Imaging in vivo

发布时间：2015-08-09      点击量：474

主讲人：Xingde Li

讲座地点：北京大学王克祯楼212会议室

讲座日期：2015-08-12

讲座时间：16:30 — 18:00

联系人：陈良怡 (Tel. 6276-4959)；程和平 (Tel. 6276-5957)

Title：Label-free Optical Technologies for Histologic Imaging in vivo

Speaker：Xingde Li, Ph.D.

Professor

Department of Biomedical Engineering

School of Medicine, Johns Hopkins University, Baltimore, USA

Time：2015年8月12日（星期三）下午4:30-6:00

Place：北京大学王克祯楼212会议室

Host：北京大学分子医学研究所  陈良怡 (Tel. 6276-4959)

         北京大学分子医学研究所  程和平 (Tel. 6276-5957)

Abstract: Recent years have witnessed the rapid development of high-resolution optical imaging technologies such as optical coherence tomography (OCT) and multiphoton microscopy, which have exhibited promising clinical translation potential for enabling label-free “histologic imaging” of biological tissue in vivo, in situ, and in real time without the need for tissue removal. This presentation will focus on our recent advances in this area, particularly on the optical micro imaging technologies, which literally miniaturize a bench-top scanning laser microscope down to a flexible fiber-optic endo- or ultra-microscope of an ~1-2 mm diameter, allowing a “microscope” to be put inside an animal or human body. The physics principles, engineering challenges, (big) data and image processing challenges, and potential solutions will be briefly discussed. Representative applications will be presented, including cancer detection, airway physiology assessment, preterm birth risk assessment, and intra-operative guidance for neurosurgery. Other potential applications towards basic research such as functional neuroimaging on awake animals will also be discussed.