报告题目：Regenerative and tumorigenic stem cell growth in the Drosophila intestine　　

　　报告人：Prof. Bruce A. Edgar　　

　　German Cancer Research Center & Center for Molecular Biology Heidelberg University　　

　　邀请人：林鑫华研究员  010-64807970　　

　　报告时间：2015年5月18日（周一）下午3:00　　

　　报告地点：中科院动物所 B105会议室　　

　　Animal and plant cells typically exist in physiologically controlled environments that are always nutrient-rich, yet they proliferate selectively. This is because specific signals from other cells stimulate or limit their growth and proliferation according to rules that benefit the organism as a whole. The goal of Dr. Edgar’s lab is to understand some of the genetic logic – or regulatory “circuitry” - that controls cell growth and coordinates it with cell cycle progression in vivo, in theDrosophila model system. 　　

　　They aim to define new genes and regulatory pathways involved in growth control that will impact general paradigms in cell and developmental biology, and which may also have relevance to topics in human health such as cancer biology, stem cell therapy, and metabolic disease.　　

　　Current topics of their interest include: Cell cycle exit at differentiation, Endocycle control, TOR signaling, and Intestinal stem cell regulation.　　

　　Awards and Fellowships:　　

　　2012    AAAS Fellow　　

　　2011    EMBO member　　

　　2010    European Research Council (ERC) “Advanced Grant”　　

　　2004    Canada Research Chair　　

　　1987    Larry Sandler Award, National Conference on Drosophila　　

　　Representative Publications:　　

1、Zielke, N., Kim, K. J., Tran, V., Shibutani, S. T., Bravo, M-J., Nagarajan, van Straaten, M. S., Woods, B., von Dassow, G., Rottig, C., Lehner, C. F., Grewal, S., Duronio, R. J., and Edgar, BA. (2011) Control of Drosophila endocycles by E2F and CRL4^Cdt2. Nature, 480:123-127

2、Reis, T., and Edgar, B. A. (2004) Negative regulation of dE2F1 by Cyclin dependent kinases controls cell cycle timing.Cell, 117:253-264

3、Prober, D.A. and Edgar, B.A. (2000) Ras promotes cellular growth in the Drosophila wing. Cell, 100:435-446

4、Neufeld, T.P., de la Cruz, A.F.A., Johnston, L.A., and Edgar, B.A. (1998) Coordination of growth and cell division in the Drosophila wing. Cell, 93:1183-1193

5、Johnston, L.A., and Edgar, B.A. (1998) Wingless and Notch regulate cell-cycle arrest in the developing Drosophilawing. Nature, 394:82-84

6、Edgar, B.A. and O'Farrell, P.H. (1990) The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell, 62:469-480