学术报告

发布日期：2016-03-25  |  来源：膜生物学国家重点实验室

报告题目：Single Cell Gene Expression Network Biology of Mammalian Organ Development　　

　　报告人：Prof.Bruce J Aronow　　

　　Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine　　

　　邀请人：林鑫华研究员 010-64807970　　

　　报告时间：2016年3月29日（周二）上午10:00　　

　　报告地点：中国科学院动物研究所C101会议室　　

　　Dr. Aronow works toward unraveling both the role and mechanism by which the functional capabilities of the human genome shape human health and our ability to adapt to stressful challenges. The Aronow lab focuses on collaborative research projects and the development of informatics systems that leverage multiple disciplines of knowledge, expertise and diverse data. The goal is to improve our collective ability to formulate high-impact inferences, hypotheses and next-stage experiments that could have the highest overall impact for biomedical research.　　

　　Heleadsa group that has extensive experience in building and analyzing cell and tissue expression profile databases, transcriptome, exome, methylation, and microRNA datatypes, and combines these with systems biology-oriented phenotype and regulatory and functional pathway and network analysis tools and resources.　　

　　The lab’s current research focus is to find or support efforts to solve problems relevant to genomic medicine by developing, both independently and collaboratively, new algorithms, tools and methodologies in translational bioinformatics. Dr. Aronow is also the first recipient of the John S. HuttonendowedChair for Biomedical Informatics.

　　Representative Publications:　　

　　1.Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a non-canonical histone signature to breast cancer.Nature, 2010; 468(7326):927-32.　　

　　2.Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y,Aronow BJ,Haigis KM, Franklin JL, Coffey RJ. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.Cell, 2012; 149(1):146-58.　　

　　3.Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T,Aronow BJ,Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, Molkentin JD. A Thrombospondin-Dependent Pathway for a Protective ER Stress Response. Cell, 2012; 149(6):1257-68.　　

　　4.Wilson EB, Yamada DH, Elsaesser H, Herskovitz J, Deng J, Cheng G, Aronow BJ,Karp CL, Brooks DG. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science, 2013; 340(6129):202-7.

5.Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, Baliga NS, Moffat J, Lin Q, Li XN, Nam DH, Lee J, Pollard SM, Zhu J, Delrow JJ, Clurman BE, Olson JM, Paddison PJ. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.Cell Rep. 2015; 13(11):2425-39.

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