学术报告

报告题目: Systematic analysis of Th17 network reveals novel IL-23 signaling circuits

报告人:  Dr. Chun Wu

Center for Neurologic Diseases, Harvard Medical School

时间:  2012 年12月4日上午10：00-11：00

地点:  动物所A501会议室

联系人：生物膜与膜生物工程国家重点实验室

赵勇 64807302

Speaker’s Selected Publication

Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regav A, Kuchroo VK. Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1. Nature (in revision);

Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Lee Y, Rangachari M, Yosef N, Kuchroo VK. Metallothioneins negatively regulate STAT1 and STAT3-mediated IL-27-induced type1 regulatory T-cell differentiation. PNAS. (in revision);

Wu C, Song J, Korpos E, Agrawal S, Cheng Y, Ninomiya M and Sorokin L. MMP-2 and MMP-9 regulate T cell transmigration across the glia limitans by dynamic balance of proinflammatory cytokines in EAE. Nat Med. (in revision);

Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic T(H)17 cells. Nat Immunol. 2012 13(10):991-9.

Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. PNAS. 2012 109(30):12105-10.

Zhu B, Kennedy JK, Wang Y, Sandoval-Garcia C, Cao L, Xiao S, Wu C, Elyaman W, Khoury SJ. Plasticity of Ly-6C(hi) myeloid cells in T cell regulation. J Immunol. 2011 187(5):2418-32

Wu C, Ivars F, Anderson P, Hallmann R, Vestweber D, Nilsson P, Robenek H, Tryggvason K, Song J, Korpos E, Loser K, Beissert S, Georges-Labouesse, E and Sorokin L. Endothelial basement membranes laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain. Nat Med. 2009 15(5):519-27;

Wu C, Rauch U, Korpos E, Song J, Loser K, Crocker PR and Sorokin L. Sialoadhesin-Positive Macrophages Bind Regulatory T Cells, Negatively Controlling Their Expansion and Autoimmune Disease Progression. J Immunol. 2009 182(10): 6508-16