学术报告
题目：Presenilin Function in Health and Alzheimer’s Disease
报告人：Sangram Sisodia, Ph.D.
Thomas Reynolds Sr. Family Professor of Neuroscience
Director, Center for Molecular Neurobiology
Department of Neurobiology, University of Chicago
时间：2012年4月19日（星期四）10：00－11：00
地点：生命科学学院208会议室
联系人：张研，62754880
Select Publications
Sisodia SS, Koo EH, Beyreuther K, Unterbeck A and Price DL: Evidence that ß amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248: 492 495, 1990.
Sisodia SS: ß-amyloid precursor protein cleavage by a membrane-bound protease. Proc. Natl. Acad. Sci. USA 89: 6075-6079, 1992
Sisodia SS, Koo EH, Hoffman PN, Perry G and Price DL: Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci. 13: 3136 3142, 1993.
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitski T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins N, Copeland N, Price DL and Sisodia SS: Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17: 181 190, 1996.
Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJS, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LHT and Sisodia SS: Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm. Nature 387: 288 292, 1997.
Borchelt DR, Ratovitski T, Van Lare J, Lee MK, Gonzales VB, Jenkins NA, Copeland NG, Price DL and Sisodia SS: Accelerated amyloid deposition in the brains of transgenic mice co expressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19: 939 945, 1997.
Buxbaum JD, Thinakaran G, Koliatsos V, O'Callahan J, Slunt HH, Price DL and Sisodia SS: Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. J. Neurosci. 18:9629-9637, 1998.
Lazarov, O. Lee, M. Peterson, DA and Sisodia SS.. Evidence that Synaptically Released Abeta Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice. J. Neurosci, 15:9785-93, 2002.
Lazarov O, Robinson J, Tang Y-P, Hairston IP, Korade-Mirnics Z, Lee V M-Y, Hersh LB, Sapolsky RB, Mirnics K and Sisodia SS. Environmental Enrichment Reduces Abeta Levels and Amyloid Deposition in Transgenic Mice. Cell, 120, 701-713, 2005
Lazarov O, Pigino G, Morfini GA, Gadadhar A, Chen X, Robinson J, Ho H,Brady ST, Sisodia SS (2007) Impairments in Fast Axonal Transport and Motor Neuron Deficits in Transgenic Mice Expressing FAD-Linked mutant PS1. J. Neuroscience, 27: 7011-7020.
Choi S, Leight SN, Lee V M-Y, Li T, Wong PC, Johnson JA, Saraiva MJ and Sisodia SS. Accelerated A? deposition in APPswe/PS1?E9 mice with hemizygous deletions of TTR (Transthyretin). J.Neuroscience, 27: 7006-7010 (2007).
Choi S, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM and Sisodia SS (2008) FAD-linked human Presenilin 1 variants impair environmental enrichment-induced hippocampal neural progenitor cell proliferation and differentiation in a non-cell autonomous manner. Neuron, 59, 568-580
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