2024年3月29日 星期五

Kinetic and Thermodynamic Control of G-Quadruplex Folding

A matter of speed: when allowed to fold in a K(+)/poly(ethylene glycol) solution, the guanine (G)-rich strand of vertebrate telomere DNA forms a parallel/antiparallel G-quadruplex, which is a (3+1) hybrid, within microseconds before slowly transforming into the parallel one within hours. Thus, the conformation that a G-quadruplex initially adopts under physiological conditions may not be the one it adopts at the equilibrium state.

Xue Y, Liu J, Zheng K, Kan Z, Hao Y, Tan Z*. (2011) Kinetic and Thermodynamic Control of G-Quadruplex Folding. Angew Chem Int Ed Engl., 50(35):8046-8050.