● 教育、工作经历

1992-1996 清华大学生物科学与技术系，学士 

1996-2001 清华大学生物科学与技术系，博士 

2001-2006 美国劳伦斯伯克利国家实验室生命科学部，博士后 

2006-2008 美国劳伦斯伯克利国家实验室生命科学部，研究科学家 

2009-2011 美国耶鲁大学分子生物物理与生物化学系，Tenure-Track助理教授 

2010.12-至今 清华大学生命科学学院，教授、博导 

2016.04-2021.04 清华大学生命科学学院院长 

● 研究兴趣、领域

利用冷冻电子显微学研究生物大分子复合体的结构与分子机理。主要研究方向如下： 

1. 更高效、更高分辨率的冷冻电镜方法学开发； 

2. 核酸质量控制的分子机制和调控； 

3. 细胞骨架和生物膜系统的协调机制。 

● 代表性论文

1. Zheng, LM, Xu J, Wang W, Gao X, Zhao C, Guo W, Sun L, Cheng H, Meng F, Chen B, Sun W, Jia X, Zhou X, Wu K, Liu Z, Ding F, Liu N*, Wang HW*, Peng HL*. (2024) Self-assembled superstructure alleviates air-water interface effect in cryo-EM. Nat Commun., 15(1):7300. 

2. Yang Z, Fan J, Wang J, Fan X, Ouyang Z*, Wang HW*, Zhou XY*. (2024) Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects. Nat Methods, 21(6):1023-1032. 

3. Xu J, Gao XY, Zheng LM, Jia X, Xu K, Ma Y, Wei XD, Liu N*, Peng HL*, Wang HW*. (2024) Graphene sandwich-based biological specimen preparation for cryo-EM analysis. Proc Natl Acad. Sci USA, 121(5):e2309384121. 

4. Zhou J, Wang A, Song Y, Liu N, Wang J, Li Y, Liang X, Li GH, Chu HY, Wang HW*. (2023) Structural insights into the mechanism of GTP initiation of microtubule assembly. Nat. Commun., 14(1):5980. 

5. You X, Zhang X, Cheng J, Xiao YN, Ma JF, Sun S, Zhang XZ*, Wang HW*, Sui SF*. (2023) In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex. Nature, 616(7955):199-206. 

6. Zheng LM, Liu N*, Gao XY, Zhu WQ, Liu K, Wu C, Yan R, Zhang JC, Gao X, Yao YT, Deng B, Xu J, Lu Y, Liu, ZM, Li MS, Wei XD*, Wang HW*, Peng HL*. (2023) Uniform thin ice on ultraflat graphene for high-resolution cryo-EM. Nat Methods, 20(1):123-130. 

7. Lu Y, Liu N*, Liu Y, Zheng LM, Yang JH, Wang J, Jia X, Zi QR, Peng HL*, Rao Y*, Wang HW*. (2022) Functionalized graphene grids with various charges for single-particle cryo-EM. Nat. Commun., 13(1):6718. 

8. Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li XM, Huang Y, Wang HW*, Ma JB*. (2022) Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607(7918):399-406. 

9. Liu N, Zheng LM, Xu J, Wang J, Hu CX, Lan J, Zhang X, Zhang J, Xu K, Cheng H, Yang Z, Gao X, Wang X, Peng HL*, Chen YN*, Wang HW*. (2021) Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM. Biophysics Reports, 7(3): 227-238. (Cover) 

10. Jin W, Wang J, Liu CP, Wang HW*, Xu RM*. (2020) Structural Basis for pri-miRNA Recognition by Drosha. Mol. Cell, 78(3): 423-439. 

11. Fan X, Wang J, Zhang X, Yang Z, Zhang JC, Zhao L, Peng HL, Lei J*, Wang HW*. (2019) Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution. Nat. Commun., 10(1):2386. 

12. Liu N, Zhang J, Chen Y*, Liu C, Zhang X, Xu K, Wen J, Luo Z, Chen S, Gao P, Jia K, Liu Z, Peng H*, Wang HW*. (2019) Bioactive Functionalized Monolayer Graphene for High-Resolution Cryo-Electron Microscopy. J. Am. Chem. Soc., 141(9):4016-4025. 

13. Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW*, Zhou JM*, Chai J*. (2019) Ligand-triggered allosteric ADP release primes a plant NLR complex. Science, 364(6435). pii: eaav5868. 

14. Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang HW*, Zhou JM*, Chai J*. (2019) Reconstitution and structure of a plant NLR resistosome conferring immunity. Science, 364(6435). pii: eaav5870. 

15. Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang Q, Wang HW*. (2018) Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173(5):1191-1203.