刘玉乐
教授
清华大学生命科学学院
邮箱:yuleliu@mail.tsinghua.edu.cn

● 教育、工作经历

1984.9-1988.7 天津南开大学生物化学专业 (学士) 

1990.9-1992.6 北京中国科学院微生物学研究所 (硕士) 

1994.9-1997.11 中国科学院微生物学研究所与英国苏格兰作物研究所联合培养博士 

1988.8-1998.9 北京中国科学院微生物学研究所 实习,助理,副研究员,研究员 

1995.5-1996.5 英国苏格兰作物研究所 访问学者 

1998.9-1999.8 美国德克萨斯大学奥斯丁分校 博士后 

1999.9-2002.8 美国耶鲁大学 博士后 

2002.9-2006.12 美国耶鲁大学 Associate Research Scientist 

2007.1 ---至今 清华大学 教授,“百人计划”责任教授 


● 研究兴趣、领域

植物免疫的信号传导与调控、植物病毒病理的分子基础、植物细胞自噬、植物功能基因组。 


● 代表性论文

1. Wang J, Chen T, Zhang Z, Song M, Shen T, Wang X, Zheng X, Wang Y, Song K, Ge X, Xu K, Qi T, Li F, Hong Y, Liu Y*. Remodelling autoactive NLRs for broad-spectrum immunity in plants, Nature 2025 Jul 16. doi: 10.1038/s41586-025-09252-z. Online ahead of print. 

2. Gong Q, Wang Y, He L, Huang F, Zhang D, Wang Y, Wei X, Han M, Deng H, Luo L, Cui F, Hong Y, Liu Y*. Molecular basis of methyl-salicylate-mediated plant airborne defence, Nature 622(7981):139-148, 2023 

3. Yang M, Ismayil A, Jiang Z, Wang Y, Zheng X, Hong Y, Li D*, Liu Y*. A viral protein disrupts vacuolar acidification to facilitate virus infection in plants, EMBO Journal 41(2): e108713, 2022 

4. Wang Y, Gong Q, Wu Y, Huang F, Ismayil A, Zhang D, Li H, Gu H, Ludman M, Fátyol, Qi Y, Yoshioka K, Hanley-Bowdoin L, Hong Y, Liu Y*. A calmodulin-binding transcription factor links calcium signaling to antiviral RNAi defense in plants, Cell Host & Microbe 29, 1393–1406, 2021 

5. Li H, Zhang D, Xie K, Wang Y, Liao Q, Hong H, Liu Y*. Efficient and high-throughput pseudorecombinant-chimeric Cucumber mosaic virus-based VIGS in maize. Plant Physiology 187(4):2865-2876, 2021 

6. Wang J, Chen T, Han M, Qian L, Li J, Wu M, Han T, Cao J, Nagalakshmi U, Rathjen JP, Hong Y, Liu Y*. Plant NLR immune receptor Tm-22 activation requires NB-ARC domain-mediated self-association of CC domain. PLoS Pathogens 16(4):e1008475, 2020 

7. Ismayil A, Yang M, Haxima Y, Wang Y, Li J, Han L, Wang Y, Zheng X, Wei X, Nagalakshmi U, Hong Y, Hanley-Bowdoin L, Liu Y*. Cotton leaf curl Multan virus βC1 protein induces autophagy by disrupting the interaction of autophagy related protein 3 with Glyceraldehyde-3 Phosphate Dehydrogenases. Plant Cell 32(4):1124-1135, 2020 

8. Ismayil A, Haxim Y, Wang Y, Li H, Qian L, Han T, Chen T, Jia Q, Yihao Liu A, Zhu S, Deng H, Gorovits R, Hong Y, Hanley-Bowdoin L, Liu Y*. Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase. PLoS Pathogens 14(8): e1007282, 2018 

9. Haxim Y, Ismayil A, Jia Q, Wang Y, Zheng X, Chen T, Qian L, Liu N, Wang Y, Han S, Cheng J, Qi Y, Hong Y, Liu Y*, Autophagy functions as an antiviral mechanism against geminiviruses in plants. eLife 6, e23897., 2017 

10. Xu G, Wang S, Han S, Xie K, Wang Y, Li J, Liu Y*, Plant Bax Inhibitor-1 interacts with ATG6 to regulate autophagy and programmed cell death. Autophagy 13(7):1161-1175, 2017 

11. Jia Q, Liu N, Xie K, Dai Y, Han S, Zhao X, Qian L, Wang Y, Zhao J, Gorovits R, Xie D, Hong Y and Liu Y*, CLCuMuB βC1 Subverts Ubiquitination by Interacting with NbSKP1s to Enhance Geminivirus Infection in Nicotiana benthamiana, PLoS Pathogens 12(6): e1005668, 2016 

12. Han S,Wang Y, Zheng X, Jia Q, Zhao J, Bai F,Hong Y and Liu Y*, Cytoplastic glyceraldehyde-3-phosphate dehydrogenases interact with ATG3 to negatively regulate autophagy and immunity in Nicotiana benthamiana, Plant Cell 27(4):1316-31, 2015 

13. Du Y, Zhao J, Chen T, Liu Q, Zhang H, Wang Y, Hong Y, Xiao F, Zhang L, Shen Q and Liu Y*, Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity, PLoS Pathogens 9(10): e1003659, 2013. 

14. Wang Y, Yu B, Zhao J, Guo J, Li Y, Han S, Huang L, Du Y, Hong Y, Tang D, and Liu Y*,Autophagy Contributes to the Leaf Starch Degradation, Plant Cell 25(4): 1383-1399, 2013 

15. Liu Y, Schiff M, Czymmek K, Talloczy Z., Levine B and Dinesh-kumar SP. Autophagy regulates programmed cell death during the plant innate immune response, Cell 121(4), 567-577, 2005 


● 荣誉、奖励及参加学术团体的情况

1997年,中国科学院青年科学家奖获得者 

2007年,清华大学“百名人才引进计划” 责任教授