学术报告

Stefan A. Muljo, Ph.D.

Tenure-Track Investigator, Integrative Immunobiology Unit NIAID, National Institutes of Health

Education:

   1994      B.A., Biology Honors Program

Johns Hopkins University, School of Arts and Sciences

  1995      M.H.S., Molecular Microbiology & Immunology

        Johns Hopkins University, School of Public Health        

  2002     Ph.D., Molecular Biology and Genetics, Graduate Program in Immunology

        Johns Hopkins University, School of Medicine 

Employment: 

  2002       Visiting Postdoctoral Researcher

        Dept. of Molecular and Cell Biology, University of California       

  2003-2008    Postdoctoral Research Fellow

        CBR Institute for Biomedical Research, Harvard Medical School, Dept. of Pathology        

  2008-present    Tenure-Track Investigator

        LI, Integrative Immunobiology Unit, NIAID, National Institutes of Health

Topic: Roles of Lin28b and microRNAs in (re)programming lymphocyte differentiation

The Integrative Immunobiology Unit is generally enamored by the RNA world. Specifically, we aim to elucidate the roles of novel non-coding RNAs and RNA-binding proteins (RBPs) in the control of lymphocyte differentiation and function.  One of our major goals is to decipher gene regulatory networks that orchestrate cell fate decisions in the hematopoietic and immune systems, since perturbations in their genetic programming underlie many diseases including cancer, immunodeficiency, autoimmunity, allergy and infectious diseases. For tractable model systems, we analyze B cell development and CD4+ T helper cell differentiation since much is already known about their core transcriptional programs and signaling pathways.  However, relatively little is known about post-transcriptional control of gene expression and the roles of non-coding RNAs in these systems. Thus, we pay special attention to novel regulatory RNAs and RBPs that may play an important role in the immune system, and employ an integrative systems biology approach to reverse engineer the molecular logic of gene expression programming.

Venue: Room143, New Biology Building, THU

Time: Mar. 11 (Monday), 2013; 16:30

Host: Prof. Li Yu

Welcome to attend!

State Key Laboratory of Biomembrane and Membrane Biotechnology