Genetic Approaches to Brain Circuit Mapping and Cell Type Characterization
发布时间:2016-04-01 点击量:584
主讲人:Hongkui Zeng
讲座地点:北京大学生命科学学院邓祐才报告厅
讲座日期:2016-04-08
讲座时间:13:00 — 14:30
联系人:饶毅
题目:Genetic Approaches to Brain Circuit Mapping and Cell Type Characterization
讲座人:Hongkui Zeng, Ph.D.
Executive Director, Structured Science
Allen Institute for Brain Science
时间:2016年4月8日,13:00 - 14:30
地点:北京大学生命科学学院邓祐才报告厅
主持人:饶毅
摘要:
The brain circuit is an intricately interconnected network of numerous cell types. Combining genetic tools with large-scale imaging and single-cell analysis technologies presents us with the opportunity to gain systematic understanding of the properties, interconnections and function of these cell types. At the Allen Institute, we are building multiple platforms, including single-cell transcriptomics, single and multi-patching electrophysiology, 3D reconstruction of neuronal morphology, high throughput brain-wide connectivity mapping, and large-scale neuronal activity imaging, to characterize the transcriptomic, physiological, morphological, and connectional properties of different types of neurons in a standardized way, towards a taxonomy of cell types and a description of their connectivity matrix for the mouse visual cortico-thalamic system. Building such knowledge base lays the foundation towards the understanding of the computational mechanisms of cortical function.