2017年3月30日 星期四
孟安明
孟安明
教授(Professor Anming Meng)

清华大学生命科学学院教授,清华—北大联合生命中心研究员。2007年当选中国科学院院士,2008年当选发展中国家科学院院士。第十一届、第十二届全国政协委员。1983年获得西南农业大学学士学位,1991年获得英国诺丁汉大学遗传学博士学位。先后获得长江特聘教授,国家杰出青年基金、香港求是基金杰出青年学者奖、何梁何利科技进步奖、谈家祯生命科学奖成就奖等。曾任等杂志编委会成员。中国科学院动物研究所所长,先后兼任中国动物学会副理事长、中国遗传学会常务理事、中国细胞生物学会理事、亚太发育生物学组织组委会成员、科技部实验动物专家委员会主任、“发育与生殖重大科学研究计划”专家组成员、国家自然科学基金委生命学部咨询专家;Current Zoology主编,Journal of Cell Science、Journal of Biological Chemistry、Cell Research 、BMC Developmental Biology、Mechanisms of  Development. 

主要研究领域(Research Interests): 

脊椎动物胚胎的分子发育生物学。利用斑马鱼为模式动物,研究胚胎的胚层诱导和图式形成的分子机理。 

Developmental biology of vertebrate embryos;

The molecular mechanisms of embryonic germ layer induction and patterning in the zebrafish.

代表性论文(selected publications,  * corresponding authors)

1.Xiong C, Liu XF, Meng AM*. 2015. The Kinase Activity-deficient Isoform of Araf Antagonizes Ras/MAPK         Signaling in the Zebrafish Embryo. Journal of Biological Chemistry, 290(42):25512-25521.

2.Xing CC, Gong B, Xue Y, Han YC, Wang YX, Meng AM*, Jia SJ *. 2015. TGF beta 1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway. Journal of Molecular Cell Biology, 7(1):48-61.

3.Xue Y, Zheng XD, Huang L, Xu PF, Ma YQ, Min ZY, Tao QH, Tao Y *, Meng AM*. 2014. Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development. Nature Communications, 5:3766.

4.Xu PF, Zhu GY, Wang YX, Sun JW, Liu XF, Chen YG *, Meng AM*. 2014. Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos. Journal of Molecular Cell Biology, 6(4):272-285.

5.Wu D, Chen LX, Sun QR, Wu XT, Jia SJ, Meng AM*. 2014. Uracil-DNA Glycosylase Is Involved in DNA Demethylation and Required for Embryonic Development in the Zebrafish Embryo. Journal of Biological Chemistry,289, 15463-15473.

6.Liu XF, Xiong C, Jia SJ, Zhang Y, Chen YG, Wang Q, Meng AM*. 2013. Araf kinase antagonizes Nodal/Smad2 activity in mesendoderm induction and patterning by directly phosphorylating Smad2 linker. Nature Communications, 4:1728:1-11.

7.Zheng XF, Yang SY, Han YC, Zhao XY, Zhao L, Tian T, Tong JY, Xu PF, Xiong C, Meng AM*. 2012. Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos. Journal of Biological Chemistry, 287(45):38254-38264.

8.Jia SJ, Dai FY, Wu D, Lin X, Xing CC, Xue Y, Wang Y, Xiao M, Wu W, Feng XH*, Meng AM*. 2012. Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos. Developmental Cell, 22(5):1065-1078.

9.Zhang M, Zhang JF, Lin SC, Meng AM*. 2012. β-catenin1 and β-catenin2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos. Development, 139(11):2009-2019.

10.Li ZQ, Wang YQ, Zhang M, Xu PF, Huang HZ, Wu D, Meng AM*. 2012. The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish. Journal of Biological Chemistry, 287(16):13005-13015.