2017年11月18日 星期六
李蓬
李蓬

教育经历:

  北京师范大学学士,1983 - 1987

  美国加州大学圣地亚哥分校博士,1992 - 1995

工作经历:

新加坡国立大学分子与细胞生物学研究所,博士后,1995-1996

美国达拉斯德州大学西南医学中心Howard Hughes医学研究所,博士后,1996 - 1997

新加坡分子和细胞生物学研究所,助理教授及研究室主任,1997-2003

香港科技大学生物系,助理教授&副教授(获终身制),2003-2006

清华大学生命科学学院,长江学者特聘教授,2006-至今

研究兴趣、领域:

代谢性疾病如肥胖症,糖尿病,动脉粥样硬化等的发生和发展机制,主要研究脂肪细胞和肝细胞中的脂肪积累,分泌及分解的分子机制以及与胰岛素敏感性的关系。在细胞水平上研究线粒体的功能,脂滴的形成,融合及与内质网的关系。

开设的课程:重大疾病的分子机制

已发表70余篇具有较高影响因子的国际论文,其中最具代表性的论文如下:

  1. Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P*2017 HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage. J Clin Invest. 127: 1353-69.
  2. Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH2, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F,Yang H, Choi CS, Savage DB, Li P*2015Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27 deficient mice. Nat. Commum. 6, 5949.
  3. Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P*2014Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth. Dev. Cell 30, 378-93.
  4. Zhang S, Shui G, Wang G, Wang C, Sun S, Zouboulis CC, Xiao R, Ye J, Li W, Li P*(2014) Cidea control of lipid storage and secretion in mouse and human sebaceous Glands, Mol. Cell. Biol. 34, 1827-38.
  5. Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu J, Yang H, Yang M and Li P*2013Perilipin1 promotes unilocular lipid droplet formation through activation of Fsp27 in adipocytes. Nat. Commum. 4, 1594
  6. Xu L, Zhou L, Li P* (2012) CIDE proteins and lipid metabolism, Arterioscler. Thromb. Vasc. Biol. 32, 1094-8.
  7. Zhou L, Xu L, Ye J, Li D, Wang W, Li X, Wu L, Wang H, Guan F, Li P*2012Cidea promotes hepatic steatosis by sensing dietary fatty acids. Hepatology 56, 95-107.
  8. Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P*2012 Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat. Med. 18, 235-43.
  9. Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P*2011Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J. Cell Biol. 195, 953-63.
  10. Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P* (2009) Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab. 9, 177-90.
  11. Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P* (2008) Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J. 27, 1537-48.
  12. Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P*(2007) Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation, Diabetes 56, 2523-32.
  13. Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P* (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genetics 35, 49-56.
  14. Chua BT, Volbracht C, Ta KOn, Li R, Yu V and Li P* (2003) Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nat. Cell Biol. 5, 1083-89.
  15. Li P, Nijhawan D, Budihardio I, Srinivasula SM, Ahmad M, Alnemri ES, and Wang X1997 Cytochrome C and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade, Cell 91, 478-89.
  16. Li P, Yang X, Wasser M, Cai Y, Chia W1997 Inscuteable and Staufen mediate asymmetric localization and segregation for Prospero RNA during Drosophila neuroblast cell divisions, Cell 90, 437-47.

荣誉、奖励及参加学术团体的情况:

中美CUSBEA奖学金,1987

新加坡国家青年科学家奖,1999

海外杰出青年人才基金,2005

享受国务院政府特殊津贴,2008

亚太分子生物学网络第一届阿瑟•科恩伯格纪念讲演奖(Arthur Kornberg Memorial Lecture award),2008

何梁何利基金生命科学领域科学与技术进步奖,2012

糖尿病/代谢研究与评论杂志编委,2006-2009

北京生物化学和分子生物学会副理事长,2006 - 至今

亚太国际分子生物学网络组织编辑顾问委员会成员,2008-

脂类生命科学国际会议指导委员会委员,2008 - 至今