2017年6月25日 星期日
唐铁山
唐铁山
教授(Professor Tie-Shan Tang)

中国科学院动物研究所研究员,博士,博士生导师。1998年获中国科学院发育生物学研究所理学博士学位,随后留所任助理研究员。2000年至2009年在美国德州大学西南医学研究中心生理系做博士后和讲师,2009年入选中国科学院动物研究所“百人计划-国外引进杰出人才”。长期从事钙信号、线粒体以及DNA修复通路与神经退行性疾病分子机理的研究,有关成果在Cell、Neuron、Mol Cell、ProgNeurobiol、PNAS、Nucleic Acids Res、Hum Mol Genet和J Neuroscience等期刊发表论文40多篇,被引用2200多篇次,H-Index目前为23。现担任中国老年学学会衰老与抗衰老科学委员会理事、北京分子生物学与生物化学学会理事,《神经药理学报》杂志编委。

 

主要研究领域(Research Interests): 

主要研究钙信号紊乱、线粒体功能异常以及DNA修复缺陷与神经退行性疾病的关系,探索以钙信号通路、DNA修复通路和线粒体为靶标的神经退行性疾病治疗方案和治疗药物。从分子、细胞到整体动物水平研究:舞蹈病、帕金森病、ALS、颅面异常痴呆综合症等神经退行性疾病的发病机制与治疗。

Dysregulation of Ca2+ signaling, mitochondrial function and DNA repair pathway in neurodegenerative diseases, such as Huntington’s disease, Parkinson’s disease, ALS, cerebrofaciothoracic (CFT) dysplasia. 

 

近年代表性论文(selected publications,  * corresponding authors)

 

1.Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y, Chen Q, Zhou A*, Tang TS*. TMCO1 is an ER Ca2+ load-activated Ca2+(CLAC) channel. Cell, 2016 (in press).
 
2.Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin YF, Huang M, Zhang T, Pei H, Chen BP, Jansen JG, de Wind N, Fischhaber PL, Friedberg EC, Tang TS*, Guo C* FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res, 2015, 43(17):8325-8339.
 
3.Xiaoling Li, Hongmei Liu, Paula L. Fischhaber, Tie-Shan Tang*. Towards therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance. Progress in Neurobiology, 2015, 132: 34-58.
 
4.WenjuanXie, Jiu-Qiang Wang, Qiao-Chu Wang, Yun Wang, Sheng Yao*, Tie-Shan Tang*. Adult neural progenitor cells from Huntington’s disease mouse brain exhibit increased proliferation and migration due to enhanced Ca2+ and ROS signals. Cell Proliferation, 2015, 48(5):517-531.
 
5.Wang F, Fischhaber PL, Guo C, Tang TS*. Epigenetic modifications as novel therapeutic targets for Huntington’s disease. Epigenomics, 2014, 6(3):287-297.
 
6.Li X, Qu F, Xie W, Wang F, Liu H, Song S, Chen T, Zhang Y, Zhu S, Wang Y, Guo C, Tang TS*. Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal. Toxicological Sciences, 2014, 139(2):452-465.
 
7.Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C, Han C, Tang TS*. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Human Molecular Genetics, 2013, 22(18): 3641-3653.
 
8.Wang JQ, Chen Q, Wang XH, Wang QC, Wang Y, Cheng HP, Guo CX, Sun QM, Chen Q, Tang TS*. Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington’s Disease. J BiolChem, 2013, 288(5): 3070-3084.
 
9.Zhifeng Wang, Fengli Wang, Tie-Shan Tang*, CaixiaGuo*. The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med., 2012, 6(2):156-64.
 
10.Hongyu Wang, Xi Chen, Yuemei Li, Tie-Shan Tang* and IlyaBezprozvanny*. Tetrabenazine is neuroprotective in Huntington’s disease mice. Molecular Neurodegeneration, 2010, 5:18.