2017年11月18日 星期六
谭铮
谭铮
教授(Professor Zheng Tan)

北京大学生命科学学院教授,博士,博士生导师。教育部“长江学者计划”特聘教授,国家杰出青年科学基金获得者。中国科学院动物研究所研究员,博士,博士生导师。教育部“长江学者计划”特聘教授,国家杰出青年科学基金获得者,中国科学院“百人计划”入选人。1982年获武汉大学生物化学学士学位,1985年获武汉大学生物物理硕士学位,1989年获中科院动物研究所细胞生物学博士学位。主持国家教委留学回国人员科研基金,中科院 “百人计划”,国家杰出青年科学基金、国家自然科学基金、国家973课题等科研项目。获2010年国家科技进步奖二等奖(排名第四)。

 

主要研究领域(Research Interests)

 

核酸G-四链体结构的产生机制与生物学功能。 

G-quadruplex structures in nucleic acids: Mechanism of formation and biological function. 

 

代表性论文(selected publications,  * corresponding authors)

 

1.Liu, H.-h., Zheng, K.-w., He, Y.-d., Chen, Q., Hao, Y.-h. and Tan, Z.* (2016) RNA G-quadruplex formation in defined sequence in living cells detected by bimolecular fluorescence complementation. Chem. Sci.

 

2. Li, X.M., Zheng, K.W., Zhang, J.Y., Liu, H.H., He, Y.D., Yuan, B.F., Hao, Y.H. and Tan, Z.* (2015) Guanine-vacancy-bearing G-quadruplexes responsive to guanine derivatives. Proc. Natl. Acad. Sci. USA, 112, 14581-14586.

 

3.Wu, R.Y., Zheng, K.W., Zhang, J.Y., Hao, Y.H. and Tan, Z.* (2015) Formation of DNA:RNA hybrid G-quadruplex in bacterial cells and its dominance over the intramolecular DNA G-quadruplex in mediating transcription termination. Angew. Chem. Int. Ed. Engl., 54, 2447-2451.

 

4. Liu, J.Q., Xiao, S., Hao, Y.H. and Tan, Z.* (2015) Strand-Biased Formation of G-Quadruplexes in DNA Duplexes Transcribed with T7 RNA Polymerase. Angew. Chem. Int. Ed. Engl., 54, 8992-8996.

 

5.Zheng, K.W., Wu, R.Y., He, Y.D., Xiao, S., Zhang, J.Y., Liu, J.Q., Hao, Y.H. and Tan, Z.* (2014) A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site. Nucleic Acids Res., 42, 10832-10844.

 

6. Zhang, J.Y., Zheng, K.W., Xiao, S., Hao, Y.H. and Tan, Z.* (2014) Mechanism and manipulation of DNA:RNA hybrid G-quadruplex formation in transcription of G-rich DNA. J. Am. Chem. Soc., 136, 1381-1390.

 

7. Xiao, S., Zhang, J.Y., Wu, J., Wu, R.Y., Xia, Y., Zheng, K.W., Hao, Y.H., Zhou, X. and Tan, Z.* (2014) Formation of DNA:RNA hybrid G-quadruplexes of two G-quartet layers in transcription: expansion of the prevalence and diversity of G-quadruplexes in genomes. Angew. Chem. Int. Ed. Engl., 53, 13110-13114.

 

8. Zheng, K.W., Xiao, S., Liu, J.Q., Zhang, J.Y., Hao, Y.H. and Tan, Z.* (2013) Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control. Nucleic Acids Res., 41, 5533-5541.

 

9. Zhang, C., Liu, H.H., Zheng, K.W., Hao, Y.H. and Tan, Z.* (2013) DNA G-quadruplex formation in response to remote downstream transcription activity: long-range sensing and signal transducing in DNA double helix. Nucleic Acids Res., 41, 7144-7152.

 

10. Xiao, S., Zhang, J.Y., Zheng, K.W., Hao, Y.H. and Tan, Z.* (2013) Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals. Nucleic Acids Res., 41, 10379-10390.
 
 
11. Wang, F., Tang, M.L., Zeng, Z.X., Wu, R.Y., Xue, Y., Hao, Y.H., Pang, D.W., Zhao, Y. and Tan, Z.* (2012) Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells. Proc. Natl. Acad. Sci. USA, 109, 20413-20418.