2017年11月18日 星期六
王强
王强
研究员(Professor Qiang Wang)

中国科学院动物研究所研究员,博士,博士生导师,胚胎发育信号转导研究组组长,国家优秀青年科学基金获得者。1999年毕业于山东大学生命科学学院,2004年获山东大学理学博士学位,2004年至2008年在清华大学生物系从事博士后工作。主要从事TGF-β家族信号转导调控机制及其在胚胎发育和组织器官形成中的功能研究,在Developmental Cell、Blood、Journal of Neuroscience、Molecular and Cellular Biology、J Biol. Chem.等主流杂志发表多篇高水平研究论文,获得教育部自然科学奖二等奖(第三完成人)。目前担任《中国实验动物学报》及《中国比较医学杂志》副主编,入选“中国科学院分子细胞科学卓越创新中心”及“中国科学院大学存济医学院岗位教授”。

 

主要研究领域(Research Interests):

 

主要利用斑马鱼为模式动物,结合分子生物学、细胞生物学、遗传学等技术,研究TGF-β/Nodal、Wnt等重要信号通路在早期胚胎发育及咽部的咽囊、软骨等相关组织器官形成中的功能及分子机理。

We are particularly interested in the roles of TGF-β/Nodal and Wnt signaling pathways during the early embryonic development and the morphogenesis of pharyngeal tissues and related organs such as pharyngeal pouches and Cartilages. Genes mediating Nodal and Wnt signaling in zebrafish embryos are being studied using  genetic, biochemical and molecular approaches. 

 

 

代表性论文(selected publications,  * corresponding authors)

 

1.Yuanqing Ma, Xiuli Liu, Zhaoting Liu, Shi Wei, Hanqiao Shang, Yu Xue, Yu Cao, Anming Meng* and Qiang Wang*. (2015). The chromatin remodeling protein Bptf promotes posterior neuroectodermal fate by enhancing Smad2-activated wnt8a expression. Journal of Neuroscience 35, 8493- 8506.
 
2.Ning, G., Liu, X., Dai, M., Meng, A.*, and Wang, Q*. (2013). MicroRNA-92a upholds Bmp signaling by targeting noggin3 during pharyngeal cartilage formation. Dev Cell 24, 283-295.
 
3.Liu, X., Xiong, C., Jia, S., Zhang, Y., Chen, Y.G., Wang, Q., and Meng, A*. (2013b). Arafkinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nat Commun4, 1728.
 
4.Liu, X., Ma, Y., Zhang, C., Wei, S., Cao, Y., and Wang, Q*. (2013a). Nodal promotes mir206 expression to control convergence and extension movements during zebrafish gastrulation. J Genet Genomics 40, 515-521. 
 
5.Liu, X., Ning, G., Meng, A.*, and Wang, Q*. (2012). MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating c-Jun N-terminal kinase 2 phosphorylation. Mol Cell Biol32, 2934-2942..
 
6.Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A.*, and Wang, Q*. (2011). Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. J BiolChem286, 28520-28532. 
 
7.Li, Y., Kang, X., and Wang, Q*. (2011). HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-beta-induced epithelial-mesenchymal transition. J Genet Genomics 38, 111-116.
 
8.  Wang, Q., Huang, Z., Xue, H., Jin, C., Ju, X.L., Han, J.D., and Chen, Y.G. (2008). MicroRNAmiR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood 111, 588-595. 
 
9.  Ma, J.#, Wang, Q.#, Fei, T., Han, J.D., and Chen, Y.G. (2007a). MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood 109, 987-994. (#Co-first author).
 
10.Wang, Q., Bai, Z., Li, X., Hou, L., and Zhang, B. (2004). The evidences of human orphan receptor COUP-TFII inhibiting telomerase activity through decreasing hTERT transcription. Cancer Lett214, 81-90.