2017年6月25日 星期日
孙育杰
孙育杰
研究员( Yujie Sun, Principal Investigator )

孙育杰,北京大学生命科学学院BIOPIC中心研究员,博士生导师。中组部青年千人。2005年在匹兹堡大学获博士学位。长期从事发展和运用单分子、超高分辨率荧光成像及操纵技术研究细胞结构与功能的关系。曾获第三届Elsevier Scopus Young Scientist Award。 

主要研究领域(Research Interests):

单分子技术已成为研究生命科学的重要手段,其终极目标之一就是在体内实时观测单分子包括生物大分子的运动,并以此在分子水平上理解生理条件下的细胞过程。我们单分子及活细胞超高分辨率成像实验室的主要方向就是开创、发展和应用新的和现有的单分子技术,包括发展超高分辨率单分子荧光成像技术和单分子操作及力学测量技术,以在单分子水平上研究活细胞,如癌细胞和干细胞的基因表达和调控,进而推动癌症治疗和干细胞研究应用。主要包括:(1)真核细胞如何利用和控制其基因转录和翻译过程中的内在以及外部噪音;(2)解析染色质的结构,分布及其在基因转录中构型改变的动力学过程。(3)最终理解细胞基因表达中脉冲过程产生和调控的机理,并用于癌症细胞以及干细胞分化机理的研究。

近年代表性论文(selected publications,  * corresponding authors)

1.Sun, Y. (2014). Super-resolution imaging with stochastic optical reconstruction microscopy (STORM) and photoactivated localization microscopy (PALM) in Optical Nanoscopy and Novel Microscopy Techniques, Xi, P., eds. (CRC Press) 

2. Chong Wang · Wanqing Du · Qian Peter Su · Mingli Zhu · Peiyuan Feng · Ying Li · Yichen Zhou · Na Mi · Yueyao Zhu · Dong Jiang · Senyan Zhang · Zerui Zhang · Yujie Sun* · Li Yu*,Dynamic tubulation of mitochondria drives mitochondrial network formation,Cell Res. 25:1108-1120. (*co-corresponding) 

3. WeijianZong, Jia Zhao, Xuanyang Chen, Yuan Lin, Huixia Ren, Yunfeng Zhang, Ming Fan, Zhuan Zhou, Heping Cheng, Yujie Sun* and Liangyi Chen*, Large-field high-resolution two-photon digital scanned light-sheet microscopy, Cell Res.,2014,5:1-4 (*co-corresponding) 

4. Zhen Liu, Dong Xing, Qian Su, Xinyu Kong, Jiamei Zhang, BoxinXue, Hao Sun, Sheng Wang, Yile Tao, Yujie Sun, Super-resolution Imaging and Tracking of Protein-Protein Interaction in Subdiffraction Cellular Space, Nature Comm. 2014,5:4443-4449 

5. Sangjin Kim&, Erik Brostr?mer&, Dong Xing&, JianshiJin&, Shasha Chong, HaoGe, Siyuan Wang, Chan Gu, Lijiang Yang, Yi Qin Gao, Xiao-dong Su*, Yujie Sun*, X. SunneyXie*, Probing Allostery Through DNA. Science 2013, 339:816-819 (*co-corresponding) 

6.  Yujie Sun, Osamu Sato, Felix Ruhnow, Mark E. Arsenault, MitsuoIkebe, and Yale E. Goldman. Single Molecule Stepping and Structural Dynamics of Myosin X. Nat StructMolBiol 2010,17, 485-491 . 

7.  Yujie Sun, Jennine D. McKenna, John M. Murray, E. Michael Ostap and Yale E. Goldman. Parallax: High Accuracy Three-Dimensional Single Molecule Tracking Using Split Images. Nano Lett 2009, 9, 2676-2682. 

8. Yujie Sun, Harry W. Schroeder III, John F. Beausang, Kazuaki Homma, MitsuoIkebe, and Yale E. Goldman. Myosin VI walks “wiggly” on actin with large and variable tilting. Mol Cell 2007, 28, 954-964. 

9. Yujie Sun, Boris Akhremitchev, Gilbert C. Walker. Using the Adhesive Interaction between AFM tips and Polymer Surfaces to Measure the Elastic Modulus of Compliant Samples. Langmuir 2004, 20, 5837-584.