2017年6月25日 星期日
张研
张研
教授(Professor Zhi-Rong Zhang)

北京大学生命科学学院教授,博士,博士生导师。国家杰出青年科学基金获得者。1997年毕业于北京大学心理学系,2003年获McGill大学博士学位。长期从事神经退行性疾病,特别是阿尔茨海默氏症中神经元凋亡及淀粉样沉积的代谢途径的研究工作,有关成果在Neuron、 PNAS、ProgNeurobiol、Nat Protocol、J Cell Biol、NeurosciBiobehav Rev、J Neurosci、Cell Death Differ、JACS等期刊发表,被引用1000多篇次。目前担任中国阿尔茨海默病防治协会理事,《Neuroscience & Biobehavioral Reviews》、《International Journal of Neuropsychopharmacology》等期刊编委。 

主要研究领域(Research Interests): 

神经退行性疾病中的细胞死亡机制研究;老年性痴呆症中的淀粉样蛋白毒性和代谢,神经元极性和生物标记物研究;在正常和应激条件下的细胞间交流研究

Cell death mechanisms in neurodegenerative diseases;Aβ metabolism, neuronal polarity and biomarks in Alzheimer’s disease;Cell-cell communication 

 

代表性论文(selected publications,  * corresponding authors) 

 

1.Sun X, Wu Y, Gu M, Liu Z, Ma Y, Li J, Zhang Y* , Selective filtering defect at the axon initial segment in Alzheimer , PNAS , 2014 , 111: 14271-14276 .
 
2.Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y*, Wang J-H*, Meijers R* , The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue , Neuron , 2014 , 83: 839-849 .
 
3.Sun X, Wu Y, Gu M, Zhang Y* , MiR-342-5p Decreases Ankyrin G Level in Alzheimer’s Disease Transgenic Mouse Models , Cell Reports , 2014 , 6: 264-270.
 
4.Cui J, Wang Y, Dong Q, Wu S, Xiao X, Hu J, Chai Z* and Zhang Y* , Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70 , J Neurosci , 2011 , 31: 16277-16240.
 
5.Wang Y, Cui J, Sun X and Zhang Y* , Tunneling-nanotube development in astrocytes depends on p53 activation , Cell Death Differ , 2011 , 18: 732-742 .
 
6.Zhang Y*, Xiong W, Lin X, Ma X and Yu L , Roles of mu-opioid receptor phosphorylation in opioid tolerance and dependence , NeurosciBiobehav Rev , 2009 , 33: 1192-1197.
 
7.Zhang Y* and Yu L* , Microinjection as a tool of mechanical delivery , CurrOpin Biotech , 2008 , 19: 506-510.
 
8.Zhang Y* , Microinjection Technique and Protocol to Single Cells , Nat Protocols , 2007 , DOI: 10.1038/nprot.2007.487 .
 
9.Zhang Y, Beitel L, Goodyer C, Trifiro M and LeBlanc A* , Estrogen and androgen protect against intracellular amyloid beta toxicity , J Neurosci , 2004 , 24: 5315-5321.
 
10.Zhang Y, Guo Y, Bounhar Y, Roucou X, Goodyer C and LeBlanc A* , p75NTR protects against extracellular amyloid beta toxicity in human neurons , J Neurosci , 2003 , 23: 7385-7394.
 
11.Zhang Y, McLauglin R, Vereker E, Goodyer C and LeBlanc A* , Selectively cytotoxicty of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons , J Cell Biol , 2002 , 156: 519-529.