2017年11月18日 星期六
肖瑞平
肖瑞平
教授(Professor Rui-Ping Xiao)

北京大学分子医学研究所所长,长江特聘教授,国家杰出青年基金获得者,国家“千人计划”特聘专家,北京大学终生讲席教授。1987年在同济医科大学生理学系获医学硕士学位;1995年获得马里兰大学生物学博士学位,2003年获聘NIH 终身资深研究员,2006年获NIH 首批女科学家顾问研究员奖。2010年3月辞去美国NIH终身资深研究员职位,全时在北京大学工作。肖瑞平教授兼具分子生物学和转化医学背景,长期从事心血管及代谢疾病药物靶点研究;迄今已在国际一流学术刊物上发表论文100余篇,引用8000余次。担任包括《新英格兰医学杂志》副主编在内的多个国际权威杂志副主编/编委。 

主要研究领域(Research Interests): 

研究方向主要集中在心血管及代谢疾病的基础和转化研究,以基础医学研究为主,重视学科交叉,走基础与临床相结合之路,总的研究目标是在基因、蛋白质和整体水平上探讨心血管及代谢疾病的发病机理及临床防治,推进转化医学。

Dr. Xiao’s research has been focused on cardiovascular and metabolic diseases, with a major emphasis on a translational approach to take bench discoveries into clinically relevant situations. Ongoing research directions include signaling pathways involved in metabolic syndrome and associated cardiovascular complications. 

代表性论文(selected publications,  * corresponding authors)

1.Zhang T, Zhang Y, Cui M, Jin L, Wang Y, Lv F, Liu Y, Zheng W, Shang H, Zhang J, Zhang M, Wu HK, Guo J, Zhang X, Hu X, Cao CM, Xiao RP*.  CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med. 2016, 22, 175-182.
 
2.Zhu W, Tsang S, Browe, DM, Woo AY, Huang Y, Xu C, Liu JF, Lv F, Zhang Y, Xiao RP*. Interaction of b1-Adrenoceptor with RAGE Mediates Cardiomyopathy via CaMKII Signaling. JCI Insight. 2016, 1, e84969. doi:10.1172/jci.insight.84969.
 
3.Liu F, Song R, Feng Y, Guo J, Chen Y, Zhang Y, Chen T, Wang Y, Huang Y, Li CY, Cao C, Zhang Y, Hu X, Xiao RP*. Upregulation of MG53 induces diabetic cardiomyopathy via transcriptional activation of PPAR-a. Circulation. 2015, 131, 795-804.
 
4.Song RS, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP*. Central Role of E3 Ubiquitin Ligase MG53 in Insulin Resistance and Metabolic Disorders. Nature. 2013, 494, 375-379.
 
5.Zhu, W., Petrashevskaya, N., Ren, S., Zhao, A., Chakir, K., Gao, E., Chuprun, J.K., Wang, Y., Talan, M., Dorn, G.W. 2nd., Lakatta, E.G., Koch, W.J., Feldman, A.M., Xiao RP*. Gi-biased b2AR signaling links GRK2 upregulation to heart failure. Circ Res. 110: 265-74, 2012.
 
6.Cao, C.M., Zhang, Y., Weislede, N., Ferrante, C., Wang, X.H., Lv, F., Zhang, Y., Song, R.S., Hwang, M., Jin, L., Guo, J., Peng, W., Li, G., Nishi, M., Takeshima, H., Ma, J., Xiao RP*. MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation. 121: 2565-74, 2010.
  
7.Peng, W., Zhang, Y., Zheng, M., Cheng, H., Zhu, W., Cao, C.M., Xiao RP*. Cardioprotection by CaMKII-dB is mediated by phosphorylation of HSF1 and subsequent expression of inducible HSP70. Circ Res. 106: 102-10, 2010.