2017年11月18日 星期六
周兵
周兵
教授(Professor Bing Zhou)

清华大学生命科学学院教授,博士,博士生导师,国家杰出青年科学基金获得者。1987年毕业于复旦大学遗传学系,1995年获加州大学伯克利分校分子细胞学博士学位,1995年至2002年在美国加州大学旧金山分校从事博士后工作。长期从事微量营养元素(主要为金属离子铁、铜、锌)代谢和相关人类疾病、以及青蒿素分子作用机制的研究,有关成果以第一作者或通讯作者身份在Nature Genetics、Elife、PNAS、Cell Reports、PLoS Genetics、Human Molecular Genetics等期刊发表论文30余篇,被引用3000多篇次。 

主要研究领域(Research Interests): 

利用果蝇从事微量营养金属元素(包括铜、铁、锌的代谢)以及在相关疾病(例如神经退行性疾病)中作用的研究;另外还利用酵母细胞、结合哺乳细胞以及疟原虫研究青蒿素的生物作用机制。研究的蛋白主要是跨膜离子转运蛋白以及线粒体呼吸链蛋白和功能调节。

The metabolism of metal ions and their roles in diseases such as neurodegenerative diseases(AD, PD, HD);  the action mechanisms of artemisinins especially their interaction with mitochondria.  

代表性论文(selected publications, *corresponding authors)

1.Huang Y, Wu Z, Cao Y, Lang M, Lu B, Zhou B*(2014). Direct Zinc Binding Is Critical for Tau Toxicity Independent of Hyperphosphorylation. Cell Reports 8(3):831-42.
2.Xiao G, Wan Z, Fan Q, Tang X, Zhou B*(2014). The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster. Elife3:e03191. doi: 10.7554/eLife.03191.
3.Xiao G, Fan Q, Wang X, Zhou B*(2013). Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding. Proc NatlAcadSci U S A. 110 (37):14995-5000.
4.Qin Q, Wang X, Zhou B*(2013). Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation. BMC Biol. 2013 Sep 24;11(1):101.
5.Feng Y, Li W, Li J, Wang J, Ge J, Xu D, Liu Y, Wu K, Zeng Q, Wu J, Tian C, Zhou B, Maojun Yang*(2012). Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature 491:478-482 (lab student co-first author)
6.Lang M*, Wang L, Fan Q, Xiao G, Wang X, Zhong Y, Zhou B*(2012). Genetic Inhibition of SLC 39 Family Transporter 1 Ameliorates Abeta Pathology in a Drosophila model of Alzheimer's Disease. PLoS Genetics 8(4):e1002683.
7.Wu Z, Li C, Lv S, Zhou B*(2009). PantothenateKinase-Associated Neurodegeneration: insights from a Drosophila model. Human Molecular Genetics18(19):3659-3672.
8.Li W, Mo W, Shen D, Sun L, Wang J, Lu S, Gitschier JM, Zhou B*(2005). Yeast model uncovers dual roles of mitochondria in the action of artemisinin.PLoS Genetics 1(3): 0329-0334.
9.Wang K, Zhou B., Kuo YM, Zemansky J. and Gitschier J*(2002). A novel member of a zinc transporter family is defective in AcrodermatitisEnteropathica. American Journal of Human Genetics71(1), 66-73.
10.Hayflick S*, Levinson B, Westaway S, Zhou B, Johnson MA, Ching KH and Gitschier J(2003). Genetic, clinical,and radiographic delineation of hallervorden-spatz syndrome. New England Journal of Medicine348, 33-40.
11.Zhou B, Westaway S, Levinson B, Johnson M., Gitschier J, Hayflick S*(2001). A novel pantothenatekinase is defective in Hallervorden-Spatz syndrome. Nature Genetics (cover), 28(4), 345-349.
12.Zhou B, Gitschier J*(1997) hCTR1: A human gene for copper uptake identified by complementation in yeast.  Proc NatlAcadSci U S A. 94, 7481-7486.