2017年6月25日 星期日
俞立
俞立
教授,博士生导师

清华大学生命科学学院教授,博士生导师。2000年于北京大学取得博士学位,之后赴美国国立卫生研究院从事博士后研究工作,2008年被聘为清华大学生命科学学院教授。自成立实验室以来,一直从事细胞自噬领域的研究。2010年首次在哺乳动物细胞中发现的自噬性溶酶体再生过程以及其调控机制。最近,俞立实验室发现了依赖细胞迁移的新细胞现象migracytosis和介导这一过程的新细胞器迁移体(Migrasoem), 目前对其分子机制进行深入的研究。俞立于2011年获得国家杰出青年基金,2012年研究成果入选2012年中国科学十大进展, 2013年获得谈家桢生命科学创新奖, 2015年入选长江学者特聘教授。 

主要研究领域(Research Interests): 

综合细胞生物学,遗传学,生物化学,分子生物学等研究方法,以从酵母到小鼠等不同模式生物为模型研究1)俞立实验室发现的新细胞器迁移体(Migrasome)的机制与功能。2)自吞噬在细胞及分子水平上的调控机制。

Li Yu’s research focuses on autophagy. His lab try to understand the autophagy in the broader context of cellular membrane trafficking system and the regulation of autophagy in the framework of metabolism regulation network. Furthermore, they are interested in studying the general principles that determine membrane curvature, shaping and remodeling by using autophagy as a working model. More specific, Li Yu’s lab focuses on two directions at this moment: 1) Migrasome, a new organelle discovered in Li Yu lab. 2) Autophagy.

代表性论文(selected publications,  * corresponding authors)

 

1.Wanqing Du, Qian Peter Su, Yang,Yueyao Zhu, Dong Jiang,YueguangRong,Senyan Zhang, Yixiao Zhang, He Ren, Chuanmao Zhang, Xinquan Wang, Ning Gao, Yanfeng Wang, Lingfei Sun, Yujie Sun* & Li Yu*. Kinesin 1drives autolysosome tabulation. Developmental Cell. in press.
2. Na Mi*, Yang Chen, Shuai Wang, Mengran Chen, Mingkun Zhao, Guang Yang, Meisheng Ma, Qian Su, Sai Luo, Jingwen Shi, Jia Xu, QiangGuo, Ning Gao, Yujie Sun, Zhucheng Chen* & Li Yu*. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nature Cell Biology. in press
3. Chong Wang, Wanqing Du, Qian Peter Su, Mingli Zhu, Peiyuan Feng, Ying Li, Yichen Zhou, Na Mi, Yueyao Zhu, Dong Jiang, Senyan Zhang, Zerui Zhang, Yujie Sun* & Li Yu* Dynamic tubulation of mitochondria drives mitochondrial network formation. Cell Research. (Cover Story) in press. 
4. Ma L, Li Y, Peng J, Wu D, Zhao X, Cui Y, Chen L, Yan X, Du Y, Yu L*. Discovery of the migrasome, an organelle mediates release of cytoplasmic contents during cell migration. Cell Research. 2015, Jan;25(1):24-38. (Cover Story)
5. Chen R, Zou Y, Mao D, Sun D, Gao G, Shi J, Liu X, Zhu C, Yang M, Ye W, Hao Q, Li R, Yu L*. The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation. Journal of Cell Biol. 2014 Jul 21;206(2):173-82.
6. YueguangRong, Mei Liu, Liang Ma, Wanqing Du, Hanshuo Zhang, Yuan Tian, Zhen Cao, Ying Li, He Ren, Chuanmao Zhang, Lin Li, She Chen, Jianzhong Xi*&Li Yu*Clathrin and phosphatidylinositol 4,5-bisphosphate regulate autophagic lysosome reformation. Nature Cell Biology, Sep;14(9):924-34
7. Cong Yi, Meisheng Ma, Leili Ran, Jingxiang Zheng, Jingjing Tong, Jing Zhu, Chengying Ma, YufenSun, ShaojinZhang, Wenzhi Feng, Liyuan Zhu, Yan Le, Xingqi Gong, Xianghua Yan, Bing Hong, Fen-Jun Jiang, ZhipingXie, Di Miao,Haiteng Deng & Li Yu1* Function and molecular mechanism of acetylation in autophagy regulation. 2012 Apr 27, 474-477, Science.
8. Ye Tian, Zhipeng Li, Wanqiu Hu, Haiyan Ren, E Tian, Yu Zhao, Qun Lu, Xinxin Huang, Peiguo Yang, Xin Li, Xiaochen Wang, Attila L. Kovács, Li Yu*, and Hong Zhang*. C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms. Cell,   2010 Jun 11;141(6):1042-1055  
9.Li Yu, Christina K. McPhee, Lixin Zheng, Gonzalo A. Mardones, YueguangRong, Junya Peng, Na Mi, Ying Zhao, Zhihua Liu, Fengyi Wan, Dale W. Hailey, Viola Oorschot, Judith Klumperman, Eric H. Baehrecke, and Michael J. Lenardo*, Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature,  2010 Jun 6
10.Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ*. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science. 2004 Jun 4; 304(5676):1500-2