2017年8月19日 星期六
颜宁
颜宁
教授(Professor Nieng Yan)

清华大学医学院教授、博士生导师、杰青、长江学者、美国霍华德休斯医学研究所首届“国际青年科学家”。颜宁2000年获得清华大学优良毕业生,2005年获Science/AAAS评选的北美地区 “青年科学家奖”;2007年受聘清华大学医学院,主要致力于重要跨膜运输蛋白及植物脱落酸受体信号通路的结构与功能机理研究,2009年至今已发表学术论文40篇,其中以通讯作者在Nature、Science、Cell发表学术论文13篇,并受邀为Annual Review in Biophysics、Current Opinion in Structural Biology、Trends in Biochemical Sciences等著名综述期刊撰写文章,其成果于2009年和2012年两次被《科学》年度十大进展引用。

 

主要研究领域(Research Interests):

 

•运用结构生物学和其他相关手段揭示膜转运蛋白的工作机理;
•运用结构生物学和生物化学的手段研究胆固醇代谢的调控机理;
•运用结构生物学和生物化学手段研究植物脱落酸信号通路的分子机理

 

代表性论文(selected publications,  * corresponding authors)

 

1.Jianping Wu, Zhen Yan, Zhangqiang Li, Chuangye Yan, Shan Lu, Mengqiu Dong, and NiengYan*.(2015) Structure of the voltage-gated calcium channel Cav1.1 complex. Science, 350(6267):aad2395.

 

2.Dong Deng, Pengcheng Sun, Chuangye Yan, MengKe, Xin Jiang, Lei Xiong, WenlinRen,Kunio Hirata, Masaki Yamamoto, Shilong Fan & NiengYan*.(2015) Molecular Basis of ligand recognition and transport by glucose transporters. Nature, 526(7573):391-6.

 

3.Ruobing Ren, Xinhui Zhou, Yuan He, MengKe, JianpingWu,Xiaohui Liu, Chuangye Yan, Yixuan Wu, Xin Gong, XiaoguangLei,S. Frank Yan, ArunRadhakrishnan, NiengYan*.(2015) Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. Science, 349(6244):187-91.

 

4.Zhen Yan,  Xiao-chen Bai,  Chuangye Yan,  Jianping Wu,  Zhangqiang Li,  Tian Xie,  Wei Peng, Chang-cheng Yin,  Xueming Li,  Sjors H. W. Scheres,  YigongShi*  & NiengYan*.(2015) Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature, 517(7532):50-5.

 

5.Dong Deng, Chao Xu,Pengcheng Sun, Jianping Wu, Chuangye Yan, Mingxu Hu & NiengYan* (2014) Crystal structure of the human glucose transporter GLUT1. Nature, 510(7503):121-5.

 

6.M. GregorMadej, Linfeng Sun, NiengYan*, and H. Ronald Kaback* (2014) Functional architecture of MFS D-glucose transporters. PNAS, 111(7):E719-27.

 

7.Ping Yin, Quanxiu Li, Chuangye Yan, Ying Liu, Junjie Liu, Feng Yu, Zheng Wang, Jiafu Long, Jianhua He, Hong-Wei Wang, Jiawei Wang, Jian-Kang Zhu, Yigong Shi & NiengYan *(2013) Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature, 504(7478):168-71.

 

8.Linfeng Sun, Xin Zeng, Chuangye Yan, Xiuyun Sun, Xinqi Gong, Yu Rao, and NiengYan*(2012). Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature, 490:361-6.

 

9.Xu Zhang, Wenlin Ren, Paul DeCaen, Chuangye Yan, Xiao Tao, Lin Tang, Jingjing Wang, Kazuya Hasegawa, Takashi Kumasaka, Jianhua He, Jiawei Wang, David E. Clapham, and NiengYan *(2012). Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature, 486: 130-134.
 
10.Dong Deng, Chuangye Yan, Xiaojing Pan, Magdy Mahfouz, Jiawei Wang, Jian-Kang Zhu, YigongShi*, and NiengYan* (2012) Structural basis for the specific recognition of DNA by TAL effectors. Science, 335: 720-3