2017年3月30日 星期四
陈晔光
陈晔光
教授(Professor Ye-Guang Chen)

清华大学生命科学学院教授,博士生导师。教育部“长江学者计划”特聘教授,国家杰出青年科学基金获得者。1996年获美国纽约爱因斯坦医学院细胞生物学博士学位。长期从事细胞信号转导方面的研究,先后在Nature、Science、Cell Stem Cell、Nat Cell Biol、Molecular Cell、Nat Commun和PNAS等期刊发表论文120多篇,被引用8000多次。曾获何梁何利科技进步奖、中国青年科技奖、美国李氏基金杰出成就奖、中国高等学校十大科技进展、新世纪百千万人才工程、中国细胞生物学会-CST杰出成就奖等。先后兼任Cell Res、JBC、Biochem J、Cell  Discovery、Intel J Biochem Cell Biol、Open Biol、中国科学(生命科学)等期刊编委,中国细胞生物学学会理事长。

主要研究领域(Research Interests):

主要利用膜生物学、分子生物学、生物化学、细胞生物学和发育生物学等多学科技术手段研究TGF-β和Wnt信号的调控以及它们在胚胎发育、干细胞自我更新和分化、肿瘤形成和组织纤维化中的作用。

His research interests concern how TGF-beta and Wnt signaling are regulated and aims to understand their roles in embryogenesis, stem cell self-renewal and differentiation, tissue fibrosis and tumorigenesis.

代表性论文(selected publications,  * corresponding authors)

1.Zhao B, Qi Z, Li Y, Wang C, Fu W, Chen YG*.  Non-muscle-myosin-II mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells via the Rac1-PAK1-Akt axis.  Nature Communications,  2015, 6:7166.
 
2.Ma B, Cao W, Li W, Gao C, Qi Z, Zhao Y, Du J, Xue H, Peng J, Wen J,  Chen H, Ning Y, Huang L, Zhang H, Gao X, Yu L, Chen YG*.  Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation. Cell Research,  2014, 24(8):912.
 
3.Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng X, Luo S, Gao C, Chen YG*.   c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.  Molecular Cell,  2013, 49(3):499.
 
4.Li, Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG*.  BMP4 signaling acts via dual specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell,  2012, 10(2):171.
 
5.Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG*.  Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation.  Nature Cell Biology,2010, 12(8):781.
 
6.Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han J*, Chen YG*.  Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Research,  2010, 20(1):36.
 
7.Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang XH*, Chen YG*.  Single-molecule imaging reveals TGF-β induced type II receptor dimerization. Proceedings of the National Academy of Sciences, USA,  2009, 106(37):15679.
 
8.Wang Q, Huang Z, Xue H, Jin C, Ju X, Han JD, Chen YG*.  MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood,  2008, 111(2):588.
 
9.Ma J, Wang Q, Fei T, Han JD, Chen YG*.  MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood,  2007, 109(3):987.
 
10.Zhang L, Zhou H, Su Y, Sun S, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG*,Meng A*.  Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors.  Science,  2004, 306(5693):114.