2017年3月30日 星期四
常智杰
常智杰
教授 (Professor Zhijie Chang)

清华大学医学院tenure教授,博士,博士生导师。1978-1989就读于西北农业大学并获博士学位,1995-1998在美国圣路易斯大学、华盛顿大学和阿拉巴马大学等医学院从事访问学者和博士后研究。1990-1995受聘西北农业大学副教授,1998-2005受聘清华大学副教授,2005年至今受聘清华大学教授。从事信号转导和肿瘤发生机理的研究,发表CancerCell, MolecularCell, Cell Research, JCB和JBC等SCI期刊论文86篇,被引用2000多篇次。获北京市科技进步三等奖,青海省科技进步一等奖。目前担任《FEBSLetter》编委。

主要研究领域(Research Interests):

 细胞信号转导和肿瘤发生的机制,特别关注STAT3, WNT和NF-kB等信号中的关键蛋白在肿瘤发生中对基因表达的调控作用。从分子、细胞、小鼠模型及病理组织等水平研究。目前课题:CREPT与信号转导调控转录的分子机制;GdX与信号转导在炎症引起的肿瘤中的作用;肿瘤干细胞在癌症发生中的作用机制。 

The mechanisms of signaltransduction and tumorigenesis, especially the regulation of STAT, WNT, and NF-kB signal pathways on gene expression during tumorigenesis. Studies are performed from molecular, cellular and mouse disease model to human pathology levels. The current projects are: the mechanisms of CREPT and signal transduction regulation on gene transcription; the effect of GdX on inflammation related tumors; the roles of tumor stem cells in tumorigenesis. 

代表性论文(selected publications,  * corresponding authors) 

Chunxiao Liu, et.al, and Zhijie Chang*. p15RS/RPRD1A Interacts with HDAC2 in Inhibition of the Wnt/b-catenin Signaling Pathway. J. Biol. Chem. 2015, Feb 19. pii: jbc.M114.620872. [Epub ahead of print]. 

Yangmeng Wang, et.al, and Zhijie Chang*. GdX/UBL4A Specifically Stabilizes the TC45/STAT3 Association and Promotes Dephosphorylation of STAT3 to Repress Tumorigenesis. Mol Cell. 53:752-765, 2014. 

ShigaoYang, et.al, Zhijie Chang*. TNFR2–IL-17RD heteromerization reveals a novel mechanism for NF-κB activation. J. Biol. Chem. 2015 Jan 9;290(2):861-71. doi: 10.1074/jbc.M114.586560. Epub 2014 Nov 5. 

Yangmeng Wang, et.al, and Zhijie Chang*. CHIP/Stub1 functions as a tumor suppressor and represses NF-κB-mediated signaling in colorectal cancer. Carcinogenesis. May;35(5):983-91, 2014. 

Yanquan Zhang, et.al, and Zhijie Chang*. CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the b-catenin/TCF4 Transcriptional Activity in Response to Wnt Signaling. J. Biol. Chem. 289(33):22589-99, 2014. 

FangliRen, et.al, and Zhijie Chang* SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma. Cellular Signalling. 25:2272-2280, 2013. 

JunweiGuo, et.al, and Zhijie Chang*. miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression. Journal of Bone and Mineral Research. 2012 Mar 9. doi: 10.1002/jbmr.1597. [Epub ahead of print] 

Fuqin Su, et.al, Kun Meng*, Zhijie Chang*. Protein tyrosine phosphatase Meg2 dephosphorylates STAT3 and suppresses tumor growth in the breast cancer. Breast Cancer Research. 2012 Mar 6;14(2):R38. [Epub ahead of print]. 

Dongdong Lu, et.al, and ZhijieChang*. CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle related genes. Cancer Cell. 21:92-104, 2012. 

Yanquan Zhang, et.al, and Zhijie Chang*. GABARAPL1 negatively regulates Wnt/b-catenin pathway by mediating Dvl2 degradation through autophagy pathway. Cellular Physiology and Biochemistry. 27:503-512, 2011.