2020年7月16日 星期四
宋默识
宋默识
研究员( Professor )

     宋默识,中国科学院动物研究所膜生物国家重点实验室研究员。

2011年于瑞典卡罗琳斯卡医学院获医学硕士学位,2015年于美国圣路易斯华盛顿大学获理学博士学位,后于美国斯坦福大学从事心血管方面的博士后研究。2018年初加入中国科学院动物研究所成立线粒体与疾病研究组。致力于线粒体调控心脏稳态和衰老的机制和干预研究,近五年发表SCI论文30余篇,Google Scholar引用次数>1200其中以(共同)第一作者身份在ScienceCellCell Metabolism (3)Circulation Research (3)Nature CommunicationsCell ReportsScience SignalingNucleic Acids Research等国际权威杂志发表SCI论文16 (平均IF>15),以通讯/共同通讯作者发表论文8篇。现任中国老年学和老年医学学会抗衰老分会副秘书长、中国动物学会理事、中国细胞生物学学会衰老细胞生物学分会委员、中国生理学会老龄生理学专业委员会委员。

 

 

主要研究领域(Research Interests):

 

利用人多能干细胞和转基因小鼠等研究模型,从线粒体质量控制、细胞代谢、表观遗传修饰等角度,解析线粒体对心脏稳态和衰老的调控机制和干预手段。

 

代表性论文(selected publications,  * corresponding authors

 1.      Li H, Wu Z, Liu X, Zhang S, Ji Q, Jiang X, Liu Z, Wang S, Qu J, Zhang W, Song M*, Song Eli*, Liu GH* (* corresponding authors).ALKBH1 deficiency leads to loss of homeostasis in human diploid cells. Protein Cell, 2020. In press.

2.      Hu H#, Ji Q#, Song M#, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Jing Y, Wang S, Zhang W, Liu GH, Qu J (# co-first authors). ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Research, 2020.doi: 10.1093/nar/gkaa425.

3.      Zhang J, Liu GH*, Qu J*, Song M*(* corresponding authors). Treating osteoarthritis via gene therapy with rejuvenation factors. Gene Therapy, 2020.doi: 10.1038/s41434-020-0149-5.

4.      Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W*, Song M*, Liu GH*, Qu J* (* corresponding authors). SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell, 2020. In press.

5.      Ma S#, Sun S#, Geng L#, Song M#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Izpisua Belmonte JC, Zhang W, Qu J, Liu GH (# co-first authors). Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell, 180:984-1001, 2020.

6.      Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH, Tang F, Qu J. A single-cell transcriptomic landscape of primate arterial aging. Nature Communications, 11:2202, 2020.

7.      Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M&, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Ma L, Esteban CR, Chan P &, Qiao J &, Zhou Q &, Izpisua Belmonte JC, Qu J, Tang F, Liu GH(& senior authors). Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell(cover article), 180:585-600, 2020.

8.      Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J, Tang F, Liu GH. Upregulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology, 17:e3000201, 2019.

9.      Geng L, Liu Z, Wang S, Sun S, Ma S, Liu X, Chan P, Sun L, Song M*, Zhang W*, Liu GH*, Qu J* (* corresponding authors). Low-dose quercetin positively regulates mouse healthspan. Protein Cell, 10:770-5, 2019.

10.  Deng L#, Ren R#, Liu Z#, Song M#, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J, Liu GH (# co-first authors). Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nature Communications, 10:3329, 2019.

11.  He X#, Song M#, Qu J, Guo Y, Cao H, Sun R, Liu GH, Shen Y, Major Program Expert Group (#co-first authors).Basic and translational aging research in China: present and future. Protein Cell, 10:476-84, 2019.

12.  Song M, Belmonte JCI,Liu GH. Age-related cardiopathies gene editing. Aging (Albany NY), 11:1327-8, 2019.

13.  Ren X#, Hu B#, Song M#, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J, Tang F, Liu GH (# co-first authors). Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis. Cell Reports, 26:3643-56, 2019.

14.  Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W*, Song M*, Qu J*, Liu GH* (* corresponding authors). Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis.Protein Cell,10:649-667, 2019.

15.  Ling C#, Liu Z#, Song M#, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q, Belmonte JCI, Wang Z, Qu J, Yuan Y, Liu GH (# co-first authors).Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. Protein Cell. 10:249-271, 2019.

16.  Wang Y, Li Y, He C, Gou B, Song M*(* corresponding author). Mitochondrial regulation of cardiac aging.Biochimica et Biophysica Acta - Molecular Basis of Disease,865:1853-64, 2019.

17.  Geng L#, Liu L#, Zhang W#*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH*(* corresponding authors). Chemical screen identifies a geroprotective role of quercetin in premature aging.Protein Cell, 10:417-35, 2019.

18.  Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S, Ding J, Chan P, Zhang W&, Song M&, Belmonte JCI&, Qu J, Tang F, Liu GH (& senior authors). FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell(cover article, accompanying editorial), 24:447-61, 2019.

19.  Wang P#, Liu Z#, Zhang X#, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J* (* corresponding authors). CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-B/RelA in maintaining the homeostasis of human vascular cells.Protein Cell, 9:945-65, 2018.

20.  Wu Z#, Zhang W#, Song M#, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J, Suzuki K, Belmonte JCI, Liu GH. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome (#co-first authors). Protein Cell, 9:333-350, 2018.

21.  Zhang W#, Song M#, Qu J, Liu GH (#co-first authors). Epigenetic modifications in cardiovascular aging and diseases. Circulation Research, 123:773-86, 2018.

22.  Song M, Franco A, Fleischer J, Zhang L, Dorn GW II. Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial aging. Cell Metabolism(cover article), 26:872-83, 2017.

23.  Song M, Mihara K, Chen Y, Scorrano L, Dorn GW II. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metabolism(featured article), 21:273-85, 2015.

24.  Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW II (#co-first authors). Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science(accompanying editorial), 350:aad2459, 2015.

25.  Song M#, Matkovich S#, Zhang Y, Hammer D, Dorn GW II (#co-first authors). Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth.Science Signaling (cover article, Podcast interview), 8:ra39, 2015.

26.  Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW II. Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts. Circulation Research(featured article, accompanying editorial), 117:346-51, 2015.

27.  Song M and Dorn GW II. Mitoconfusion: Non-canonical functioning of dynamism factors in static mitochondria of the heart. Cell Metabolism, 21:195-205, 2015.

28.  Shirihai OS, Song M, Dorn GW II. How mitochondrial dynamism orchestrates mitophagy. Circulation Research, 116:1835-49, 2015.

29.  Dorn GW II, Song M, Walsh K. Functional implications of mitofusin 2-mediated mitochondrial-SR tethering. Journal of Molecular and Cellular Cardiology, 78C:123-8, 2015.

30.  Song M, Chen Y, Gong G, Murphy E, Rabinovitch P, Dorn GW II. Super-suppression of mitochondrial ROS signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circulation Research (cover article, featured article, accompanying editorial), 115:348-53, 2014.

31.  Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW II. Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circulation Research, 114:257-65, 2014.

联系方式

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北京市朝阳区大屯路甲3号,干细胞与再生医学创新研究院