2019年7月23日 星期二
宋默识
宋默识
研究员( Professor Mo-Shi Song)

心脏稳态对于机体应对外界环境压力和内稳态的变化具有重要意义。心脏稳态失调引起心力衰竭、心肌肥大等多种心血管疾病。线粒体参与心肌细胞能量代谢、氧化应激、细胞命运决定等多方面的生命活动。因此,解析线粒体如何调控心脏稳态具有十分重要的理论和应用价值。宋默识研究员实验室利用人多能干细胞和小鼠等多模型体系,从线粒体自噬、动态、DNA、代谢、表观遗传等多角度研究线粒体质量控制对于心脏疾病和衰老的调控机制和干预手段。

教育经历: 

2011-2015,博士,分子细胞生物学美国圣路易斯华盛顿大学

2009-2011,硕士,生物医学瑞典卡罗琳斯卡医学院

2005-2009,学士,生物科学,北京林业大学

 

工作经历:  

2018-至今,研究员,中国科学院动物研究所

2016-2018,博士后,美国斯坦福大学

 

荣誉奖励: 

美国心脏协会 (AHA) Postdoctoral Fellowship
美国心脏协会 (AHA) Predoctoral Fellowship
中国国家优秀留学生奖
圣路易斯华盛顿大学Spencer T. and Ann W. Olin Medical Science Fellow奖
圣路易斯华盛顿大学Barbara Jakschik Award奖
美国心脏协会心血管基础研究协会年会 (BCVS) 优秀青年研究学者奖
国际心脏病研究会北美分会年会 (ISHR-NAS) 优秀青年研究学者奖
《Circulation Research》杂志年度最佳论文奖
EMBO Workshop线粒体质量控制研讨会最佳海报奖
Gordon Research Conference心脏调节机制研讨会最佳海报奖
Keystone Symposium心脏重塑、信号通路、基质及功能研讨会优秀青年研究学者奖

 

学术兼职: 

2018-委员,中国细胞生物学学会衰老细胞生物学分会

2018-委员,中国老年学和老年医学学会抗衰老分会

2015-会员,中国病理生理学会心血管专业委员会

2015-会员,国际心脏病研究会北美分会 (ISHR-NAS)

2013-会员,美国心脏协会 (AHA)

Autophagy》、《The FASEB Journal》、《Stem Cell Reports》等杂志特约审稿人

 

代表性论文(selected publications,  * corresponding authors) 

  1. Geng L#, Liu L#, Zhang W#*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH* (* corresponding authors). Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell, 2018. Doi: 10.1007/s13238-018-0567-y.
  2. Wang P#, Liu Z#, Zhang X#, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J* (* corresponding authors). CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell, 2018. Doi: 10.1007/s13238-018-0560-5.
  3. Song M, Franco A, Fleischer J, Zhang L, Dorn GW II. Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial aging. Cell Metabolism (cover article), 26:872-83, 2017.
  4. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW II. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metabolism (featured article), 21:273-85, 2015.
  5. Song M and Dorn GW II. Mitoconfusion: Non-canonical functioning of dynamism factors in static mitochondria of the heart. Cell Metabolism, 21:195-205, 2015.
  6. Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW II (# co-first authors). Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science (accompanying editorial), 350:aad2459, 2015.
  7. Song M#, Matkovich S#, Zhang Y, Hammer D, Dorn GW II (# co-first authors). Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth. Science Signaling (cover article, Podcast interview), 8:ra39, 2015.
  8. Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW II. Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts. Circulation Research (featured article, accompanying editorial), 117:346-51, 2015.
  9. Song M, Chen Y, Gong G, Murphy E, Rabinovitch P, Dorn GW II. Super-suppression of mitochondrial ROS signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circulation Research (cover article, featured article, accompanying editorial), 115:348-53, 2014.
  10. Zhang W#, Song M#, Qu J, Liu GH (# co-first authors). Epigenetic modifications in cardiovascular aging and diseases. Circulation Research, 2018. [in press]
  11. Shirihai OS, Song M, Dorn GW II. How mitochondrial dynamism orchestrates mitophagy. Circulation Research, 116:1835-49, 2015.
  12. Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW II. Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circulation Research, 114:257-65, 2014.