2019年8月20日 星期二
李毓龙
李毓龙
研究员( Professor Yu-Long Li)

他们实验室集中在神经元通讯的基本结构突触上,从两个层面上开展研究:一是开发前沿的工具,即开发新型成像探针,用于在时间和空间尺度上解析神经系统的复杂功能;二是借助先进的工具探究突触传递的调节机制,特别是在生理及病理条件下对神经递质释放的调节。

教育经历: 

2000 - 2006,博士,神经生物学,美国杜克大学

1996 - 2000,学士,生命科学学院,北京大学

 

工作经历:  

2012 - 至今,研究员,北京大学生命科学学院,北京大学麦戈文脑研究所,北大清华生命联合中心,

2006 - 2012,博士后,斯坦福大学

 

荣誉奖励: 

2015     绿叶生物医药杰出青年学者奖

2015     北京大学生命科学学院十佳教师

2014     中组部青年千人计划

2006     杜克大学神经生物学最佳博士论文奖(The Somjen Prize 

 

学术兼职: 

美国神经科学学会会员

中国生理学会青年工作委员会委员 

 

代表性论文(selected publications,  * corresponding authors) 

  1. Jing, M., Zhang, P., Wang, G., Feng, J., Mesik, L., Zeng, J., ... & Li, Y.* (2018). A genetically-encoded fluorescent acetylcholine indicator. Nature Biotechnology, in press.
  2. Wang, H., Jing, M., & Li, Y.* (2018). Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Current Opinion in Neurobiology, 50, 171-178. (Review)
  3. Wang, A., Feng, J., Li, Y.*, & Zou, P.* (2018). Beyond Fluorescent Proteins: Hybrid and Bioluminescent Indicators for Imaging Neural Activities. ACS chemical neuroscience, 9(4), 639-650. (Review)
  4. Qian, C., & Li, Y.* (2015). Spine maturation and pruning during development: Cadherin/Catenin complexes come to help. Science China. Life sciences,58(9), 929. (Preview)
  5. Shen, Y., Ge, W. P., Li, Y., Hirano, A., Lee, H. Y., Rohlmann, A., ... & Ptacek, L. J. (2015). Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. Proceedings of the National Academy of Sciences, 112(10), 2935-2941.
  6. Liang, L., Li, Y., Potter, C. J., Yizhar, O., Deisseroth, K., Tsien, R. W., & Luo, L. (2013). GABAergic Projection Neurons Route Selective Olfactory Inputs to Specific Higher-Order Neurons. Neuron, 79(5), 917-931.
  7. Li, Y.*, & Tsien, R. W.* (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nature neuroscience, 15(7), 1047-1053.
  8. Park, H., Li, Y., & Tsien, R. W. (2012). Influence of synaptic vesicle position on release probability and exocytotic fusion mode. Science, 335(6074), 1362-1366.
  9. Yoo, A. S., Sun, A. X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., ... & Crabtree, G. R. (2011). MicroRNA-mediated conversion of human fibroblasts to neurons. Nature, 476(7359), 228-231.
  10. Zhang, Q., Li, Y., & Tsien, R. W. (2009). The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science, 323(5920), 1448-1453.
  11. Kuner, T., Li, Y., Gee, K. R., Bonewald, L. F., & Augustine, G. J. (2008). Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release. Proceedings of the National Academy of Sciences, 105(1), 347-352.
  12. Li, Y., Augustine, G. J., & Weninger, K. (2007). Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events. Biophysical journal, 93(6), 2178-2187.